Life Extension - Pathology
Hyperinsulinemia (Insulin Resistance) -
updated: 16 December 2008
Hyperinsulinemia and aging
Nippon Rinsho. 2007 Jun;65(6):1147-54
Minamino T, Komuro I.
Aging was thought to be a haphazard process, which was not driven by any defined mechanisms. Recently, it has been reported that changing in single gene expression can extend lifespan. Many mutations that extend lifespan are involved in endocrine signaling. The mechanisms of longevity by such mutations are conserved among various species ranging from yeast to mice. One of the most important pathways underlying the regulation of longevity is the insulin signal pathway. In this review, we will describe long-lived animals that have mutations in this pathway
Publication Types:
Online - Abstract
Diabetes and aging: epidemiologic overview
Clin Geriatr Med. 2008 Aug;24(3):395-405, v.
Morley JE.
Diabetes mellitus has long been recognized as a cause of accelerated aging. As the understanding of the metabolic syndrome has evolved, it has been recognized that the interaction of a panoply of factors in the presence of insulin resistance results in accelerated aging. This article explores the increasing prevalence of diabetes mellitus with aging and how insulin resistance leads to accelerated frailty, disability, hospitalization, institutionalization, and death.
Publication Types:
Online - Abstract
Impaired insulin signaling and human ageing
Postepy Hig Med Dosw (Online). 2008 May 29;62:263-71
Ksiazek K, Witowski J.
Human ageing is associated with impaired insulin activity, which may lead to alterations in energy homeostasis and type 2 diabetes. In addition, increasing evidence suggests that type 2 diabetes-associated hyperglycemia and hyperinsulinemia may accelerate cellular senescence. On the other hand, impaired insulin signaling in animal models extends organismal lifespan and interventions that promote longevity prevent metabolic alterations and diabetes. Here, we review the mechanisms underlying the development of age-associated hyperglycemia, its impact on cellular senescence and the effect of insulin-signaling pathways on energy balance and ageing.
Publication Types:
Online - Abstract
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