Life Extension - Pathology
Silent Iinformation Regulator 1 (SIRT1) -
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The anti-aging, metabolism potential of SIRT1
Curr Opin Investig Drugs. 2008 Oct;9(10):1095-102
Ghosh HS.
SIRT1 (sirtuin 1) is the human ortholog of the yeast Sir2 (silent information regulator 2) protein, which is implicated in lifespan extension in model organisms, such as yeast, worms and flies. It is an NAD+-dependent protein deacetylase with over two dozen known substrates that affect a wide variety of cellular processes, ranging from metabolism, cell cycle, growth and differentiation, inflammation, senescence, apoptosis, stress response and aging. Even though SIRT1 has been linked to calorie restriction-mediated longevity in model organisms, the mechanism by which it extends lifespan in mammals is not fully understood. A growing body of evidence suggests a role of SIRT1 in maintaining energy and nutrient homeostasis, thereby linking its anti-aging property to its role in metabolism.
Publication Types:
Online - Abstract
SIRT1: roles in aging and cancer
BMB Rep. 2008 Nov 30;41(11):751-6
Kim EJ, Um SJ.
Aging and cancer both occur as a result of accumulated cellular damage, and both are related to the regulation of specific genes in the damage response. Recent research has unveiled connections between the mechanisms of aging and cancer, but how to prevent the development of cancer and increase longevity remain unknown. SIRT1 (the mammalian Sir2), which has NAD(+)-dependent class III histone deacetylase activity, may be a key gene linking the modulation of cancer and aging. SIRT1 has broad biological functions in growth regulation, stress response, tumorigenesis, endocrine signaling, and extended lifespan. Here, we focus on the current knowledge regarding the role of SIRT1 in aging and cancer, and discuss the implications of SIRT1 as a therapeutic target for the optimal balance between anti-aging and anti-cancer activities.
Publication Types:
Online - Article
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